New substrates, new inhibitors and the stereochemistry of the succinic dehydrogenase system

O Gawron, AJ Glaid, TP Fondy…

Index: Gawron,O. et al. Journal of the American Chemical Society, 1962 , vol. 84, p. 3877 - 3882

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Citation Number: 32

Abstract

L-Chlorosuccinate and L-methylsuccinate are substrates for succinic dehydrogenase, chlorofumarate and mesaconate being produced, respectively, by enzyme catalyzed dehydrogenation. The respective enantiomorphs, D-chlorosuccinate and L-methylsuccinate, are inhibitors of the enzyme and the stereospecificity of succinic dehydrogenase is thereby established. The enzyme exhibits a trans stereoselectivity, dehydrogenating erythro-3- ...