Synthetic studies towards 4, 10-diaza-1, 7-dioxaspiro [5.5] undecanes: access to 3-aza-6, 8-dioxabicyclo [3.2. 1] octan-2-one and 2H-1, 4-oxazin-3 (4H)-one …
M Goubert, L Toupet, ME Sinibaldi, I Canet
Index: Goubert, Marlene; Toupet, Loic; Sinibaldi, Marie-Eve; Canet, Isabelle Tetrahedron, 2007 , vol. 63, # 34 p. 8255 - 8266
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Citation Number: 10
Abstract
Synthetic approaches towards 4, 10-diaza-1, 7-dioxaspiro [5.5] undecanes starting from 1, 3- dichloroacetone and solketal derivatives are explored. The method relies on the preparation of a key bis-substituted dihydroxy-protected oxime, which would undergo a final acidic deprotection–spiroacetalization process. Although the desired diazaspiroketal framework could not be obtained, our conditions led to the unexpected 3-aza-6, 8-dioxabicyclo [3.2. 1 ...
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