Synlett

N-Carbamylamino alcohols as the precursors of oxazolidinones via nitrosation-deamination reaction

…, T Yamazaki, H Ohta, K Shima, K Ohi, S Nishiyama…

Index: Suzuki, Masumi; Yamazaki, Takahiro; Ohta, Hiromichi; Shima, Kyoko; Ohi, Katsuhide; Nishiyama, Shigeru; Sugai, Takeshi Synlett, 2000 , # 2 p. 189 - 192

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Citation Number: 19

Abstract

Abstract: Oxazolidinones were effectively prepared from N-carbamylamino alcohols by treatment with nitrous acid, via N-nitroso compound as the intermediate. A new route to (R)-4- benzyloxazolidinone was developed starting from DL-phenylalanine, utilizing D- hydantoinase-catalyzed enantioselective hydrolysis of 5-benzylhydantoin under the dynamic kinetic resolution conditions, and the subsequent reduction to the precursor for ...