Stereoselective synthesis of 2-aryloxy esters: An asymmetric approach to fluoxetine, tomoxetine and nisoxetine

PN Devine, RM Heid, DM Tschaen

Index: Devine, Paul N.; Heid Jr., Richard M.; Tschaen, David M. Tetrahedron, 1997 , vol. 53, # 20 p. 6739 - 6746

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Citation Number: 50

Abstract

Serotonin and norepinephrine uptake inhibitors have proven to be indispensible for the treatment of psychiatric disorders such as anxiety and clinical depression) In addition, several members of this class have shown promise for the treatment of alcoholism, chronic pain and eating disorders such as obesity and bulimia. 2 Fluoxetine, marketed under the trade name Prozac®, has recently surpassed the $2 billion mark in annual sales. The four ...