Synthesis and anti??inflammatory evaluation of 3??methylthio??1, 2, 4??triazines, 3??alkoxy??1, 2, 4??triazines, and 3??aryloxy??1, 2, 4??triazines

WP Heilman, RD Heilman, JA Scozzie…

Index: Heilman; Scozzie; Wayner; Gullo; Ariyan Journal of Pharmaceutical Sciences, 1980 , vol. 69, # 3 p. 282 - 287

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Citation Number: 27

Abstract

Abstract To develop nonacidic, nonsteroidal anti-inflammatory agents without GI complications, a series of asymmetric triazines was synthesized and evaluated for anti- inflammatory efficacy in the carrageenan-induced pedal edema assay. Toxicity was estimated by determination of approximate LD 50 values in mice. Twenty-five compounds possessed activity comparable to the standard, indomethacin. Thirteen of the 25 ...