Analogs of cisplatin derived from diaminodideoxytetritols. Synthesis and activity against the ADJ/PC6 plasmacytoma in mice

AH Haines, C Morley, BA Murrer

Index: Haines, Alan H.; Morley, Christopher; Murrer, Barry A. Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 742 - 745

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Citation Number: 19

Abstract

Continuing interesP4 in the development of analogues of the anticancer drug cisplatin (11, which, for example, are less toxic, have increased clinical efficacy and have a broader spectrum of activity than the parent compound, and recent report^^,^ of analogues containing diamino carbohydrate derivatives, led us to prepare four new complexes 2-5, each of which contain a diaminodideoxytetritl derivative in place of the amine ligands ...