Copyrine alkaloids: synthesis, spectroscopic characterization, and antimycotic/antimycobacterial activity of A-and B-ring-functionalized sampangines

…, JK Zjawiony, S Liu, CD Hufford, AM Clark…

Index: Peterson; Zjawiony; Liu; Hufford; Clark; Rogers Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4069 - 4077

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Citation Number: 84

Abstract

Several A-and B-ring-substituted sampangines were synthesized and evaluated for antifungal and antimycobacterial activity against AIDS-related opportunistic infection pathogens. Electrophilic halogenation provided a channel for structural elaboration of the sampangine B-ring at position 4, while the synthesis of A-ring 3-substituted sampangines and benzo [4, 5lsampangine (24) were achieved from the corresponding functionalized ...