Arzneimittelforschung

Large-scale Synthesis of GMP Grade α-Cyano-β-hydroxy-β-methyl-N-(2, 5-dibromophenyl) propenamide (LFM-A13), a New Anti-cancer Drug Candidate

D DuMez, TK Venkatachalam…

Index: DuMez, Darin; Venkatachalam, Taracad K.; Uckun, Fatih M. Arzneimittel-Forschung/Drug Research, 2007 , vol. 57, # 3 p. 155 - 163

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Citation Number: 2

Abstract

Abstract The leflunomide (CAS 75706-12-6) metabolite (LFM) analog α-cyano-β-hydro-xy-β- methyl-N-(2, 5-dibromophenyl)-propenamide (LFM-A13, DDE-28, CAS 244240-24-2), is a rationally designed inhibitor of the anti-apoptotic enzyme Bruton's tyrosine kinase (BTK). LFM-A13 is being developed as a novel dual-function anti-cancer drug with apoptosis- promoting and anti-thrombotic properties. LFM-A13 was prepared under current Good ...