Journal of medicinal chemistry

Structure-activity studies of cerulenin analogues as protein palmitoylation inhibitors

DS Lawrence, JT Zilfou, CD Smith

Index: Lawrence, David S.; Zilfou, Jack T.; Smith, Charles D. Journal of Medicinal Chemistry, 1999 , vol. 42, # 24 p. 4932 - 4941

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Citation Number: 87

Abstract

Activation of ras oncogenes occurs in a high percentage of tumors, making the enzymes involved in the posttranslational processing of their encoded proteins (p21s) attractive targets for the development of new drugs. Although most effort has focused on farnesyl transferase, which catalyzes the first processing step, attachment of palmitate to p21 is required for optimal transformation by H-ras and N-ras. We have demonstrated that the ...