6-Methyl-2, 4-disubstituted pyridazin-3 (2H)-ones: a novel class of small-molecule agonists for formyl peptide receptors

…, MJ Rabiet, C Biancalani, N Cesari…

Index: Buerli, Roland W.; Xu, Han; Zou, Xiaoming; Muller, Kristine; Golden, Jennifer; Frohn, Mike; Adlam, Matthew; Plant, Matthew H.; Wong, Min; McElvain, Michele; Regal, Kelly; Viswanadhan, Vellarkad N.; Tagari, Philip; Hungate, Randall Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 14 p. 3713 - 3718

Full Text: HTML

Citation Number: 24

Abstract

... Treatment of the commercially available 6-methylpyridazinone 26 with m-methoxybenzyl chloride in acetonitrile resulted in compound 27, which, in turn, gave the corresponding 4-amino derivative 28 by heating with N 2 H 4 under hard conditions. ...