Novel imidazo [1, 2-a] pyridine based inhibitors of the IGF-1 receptor tyrosine kinase: optimization of the aniline

…, CD Jones, FH Jung, I Simpson, J Curwen…

Index: Ducray, Richard; Jones, Clifford D.; Jung, Frederic H.; Simpson, Iain; Curwen, Jon; Pass, Martin Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 16 p. 4702 - 4704

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Citation Number: 20

Abstract

Following the discovery of imidazopyridine 1 as a potent IGF-1R tyrosine kinase inhibitor, the aniline part has been modified with the aim to optimize the properties of this series. The structure–activity relationships against IGF-1R kinase activity as well as inhibition of the hERG ion channel are discussed.

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