European journal of medicinal chemistry

Synthesis and inhibition of PGE 2 production of 6, 8-disubstituted chrysin derivatives

H Park, TT Dao, HP Kim

Index: Park, Haeil; Tran, Thanh Dao; Hyun, Pyo Kim European Journal of Medicinal Chemistry, 2005 , vol. 40, # 9 p. 943 - 948

Full Text: HTML

Citation Number: 43

Abstract

A series of 6, 8-disubstituted chrysin derivatives have been synthesized and evaluated for their PGE2 inhibitory activities. 6, 8-Disubstituted chrysin derivatives were obtained from naturally occurring chrysin by halogenation, oxidation, thiomethylation and C–C cross coupling reaction. Among the compounds investigated, 6, 8-dibromochrysin (2), 6, 8- diiodochrysin (4), 6, 8-dimethylthiochrysin (9) and 6, 8-dimethoxychrysin (11) showed as ...