Journal of the American Chemical Society

Total synthesis of the major human urinary metabolite of prostaglandin D2, a key diagnostic indicator

EJ Corey, K Shimoji

Index: Corey, E. J.; Shimoji, Katsuichi Journal of the American Chemical Society, 1983 , vol. 105, # 6 p. 1662 - 1664

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Citation Number: 49

Abstract

2-1-agnosis and proper treatment of this and other human illnesses in which PGD, is overproduced could in principle be facilitated by a urinary immunoassay for the major metabolite of PGD,, the diketo acid 2.2 Surprisingly this key substance, which is not available in significant amount from any natural source, has not previously been synthesized. We report herein a practical synthetic route to 2 that also introduces several ...