Tetrahedron Letters

Enantioselective Grignard addition to nitroolefin

P Reddy, R Bandichhor

Index: Reddy, Prashanth; Bandichhor, Rakeshwar Tetrahedron Letters, 2013 , vol. 54, # 30 p. 3911 - 3915

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Citation Number: 2

Abstract

A novel synthesis of naproxen utilizing nitroaldol, 1, 4-addition and Nef reaction is demonstrated where the desired S-enantiomer is achieved by resolution. Further to this first enantioselective 1, 4-addition of Grignard reagent to nitroolefin is demonstrated to synthesize derivatives of naproxen.

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