Selective Type IV Phosphodiesterase Inhibitors as Antiasthmatic Agents. The Syntheses and Biological Activities of 3-(Cyclopentyloxy)-4-methoxybenzamides and …

…, G Fenton, JA Karlsson, MN Palfreyman…

Index: Ashton, Michael J.; Cook, David C.; Fenton, Garry; Karlsson, Jan-Anders; Palfreyman, Malcolm N.; et al. Journal of Medicinal Chemistry, 1994 , vol. 37, # 11 p. 1696 - 1703

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Citation Number: 139

Abstract

Asthma is characterized by variable airflow obstruction, pulmonary eosinophilia, and airway hyperresponsiveness. These symptoms are believed to be a consequence of a chronic inflammation of the airway mucosa, and in addition to eosinophils, many other inflammatory cells such as mast cells, lymphocytes, and macrophages are also present in increased numbers in asthmatic airway tissue. lv2 Proinflammatory mediators and proteins ...