Rhodium??Catalyzed Asymmetric Hydrogenation of Olefins with PhthalaPhos, a New Class of Chiral Supramolecular Ligands

L Pignataro, M Boghi, M Civera…

Index: Pignataro, Luca; Boghi, Michele; Civera, Monica; Carboni, Stefano; Piarulli, Umberto; Gennari, Cesare Chemistry - A European Journal, 2012 , vol. 18, # 5 p. 1383 - 1400

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Citation Number: 34

Abstract

Abstract A library of 19 binol-derived chiral monophosphites that contain a phthalic acid diamide group (PhthalaPhos) has been designed and synthesized in four steps. These new ligands were screened in the rhodium-catalyzed enantioselective hydrogenation of prochiral dehydroamino esters and enamides. Several members of the library showed excellent enantioselectivity with methyl 2-acetamido acrylate (6 ligands gave> 97% ee), methyl (Z)- ...

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