Biphenyl/diphenyl ether renin inhibitors: filling the S1 pocket of renin via the S3 pocket

J Yuan, RD Simpson, W Zhao, CM Tice, Z Xu…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 16 p. 4836 - 4843

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Citation Number: 10

Abstract

... Please enable JavaScript to use all the features on this page. Bioorganic & Medicinal Chemistry Letters. ... In this Letter, we describe the successful realization of this design strategy to afford potent, orally bioavailable renin inhibitors. ...