Tetrahedron letters

Spirobicyclic diamines 1: synthesis of proline-derived spirolactams via thermal intramolecular ester aminolysis

F Kelleher, S Kelly

Index: Kelleher, Fintan; Kelly, Sinead Tetrahedron Letters, 2006 , vol. 47, # 18 p. 3005 - 3008

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Citation Number: 13

Abstract

Proline-derived [4.4]-spirolactams have been synthesised in good yields by a reductive- amination reaction followed by thermal cyclisation of the resulting amine onto the proline ester group in refluxing toluene. The synthesis of the corresponding [4.5]-spirolactams by the same method gave much reduced yields.