An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity
B Budke, JH Kalin, M Pawlowski…
Index: Journal of Medicinal Chemistry, , vol. 56, # 1 p. 254 - 263
Full Text: HTML
Citation Number: 34
Abstract
... Journal of Medicinal ... University of Chicago, 5758 S. Maryland Avenue, Chicago, Illinois 60637, United States. ‡ Department of Medicinal Chemistry and Pharmacognosy ... To overcome this problem, we generated chemical analogues that maintain binding to RAD51 but lack the ...
Related Articles:
Discovery and structural optimization of pyrazole derivatives as novel inhibitors of Cdc25B
[Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 9 p. 2876 - 2879]
Development of Small Molecules that Specifically Inhibit the D-loop Activity of RAD51
[Budke, Brian; Kalin, Jay H.; Pawlowski, Michal; Zelivianskaia, Anna S.; Wu, Megan; Kozikowski, Alan P.; Connell, Philip P. Journal of Medicinal Chemistry, 2013 , vol. 56, # 1 p. 254 - 263]