New quinolinic derivatives as centrally active antioxidants

G Dorey, B Lockhart, P Lestage, P Casara

Index: Dorey, Gilbert; Lockhart, Brian; Lestage, Pierre; Casara, Patrick Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 9 p. 935 - 939

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Citation Number: 70

Abstract

Oxidative damage of cellular components such as proteins, unsaturated fatty acids and DNA have been associated with biological disorders such as cancer, stroke, and post-ischaemic or age-related neuronal degeneration. 1 and 2 Furthermore, the high levels of oxygen consumption, unsaturated fatty acids and iron stores, combined with the low antioxidant capacity and absence of neuronal regeneration, make the brain extremely susceptible to radical- ...