New structures able to prevent the inhibition by hydroxyl radicals of glutamate transport in cultured astrocytes

I Cauquil-Caubère, JM Kamenka

Index: Cauquil-Caubere, Isoline; Kamenka, Jean-Marc European Journal of Medicinal Chemistry, 1998 , vol. 33, # 11 p. 867 - 877

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Citation Number: 14

Abstract

4, 5, 6, 7-Tetrahydro-benzothiophen-7-ylamines, 4, 5, 6, 7-tetrahydro-benzothiophen-4- ylamines, and 5, 6-dihydro-4H-thieno [2, 3-b] thiopyran-4-ylamines were designed, synthesized, and tested as OH• radical scavengers. Most of them displayed chemical scavenging properties better than or in the same range as salicylic acid. Moreover, some compounds were able to protect in vitro the astroglial glutamate transporters against ...