N 6-Cycloalkyl-2-phenyl-3-deaza-8-azaadenines: a new class of A 1 adenosine receptor ligands. A comparison with the corresponding adenines and 8-azaadenines

…, A Nardi, F Pacchini, V Scartoni, A Lucacchini

Index: Biagi, Giuliana; Giorgi, Irene; Livi, Oreste; Nardi, Antonio; Pacchini, Federica; Scartoni, Valerio; Lucacchini, Antonio European journal of medicinal chemistry, 2003 , vol. 38, # 11-12 p. 983 - 990

Full Text: HTML

Citation Number: 14

Abstract

Several 9-benzyl-N6-cycloalkyl-2-phenyladenines, 9-benzyl-N6-cycloalkyl-2-phenyl-8- azaadenines and 4-cycloalkylamino-1-benzyl-6-phenyl-1H-1, 2, 3-triazolo [4, 5-c] pyridines were prepared and assayed as A1 adenosine receptor ligands. The 1H-1, 2, 3-triazolo [4, 5- c] pyridines were obtained starting from N, N-diethyl-1-benzyl-4-carboxyamido-5-methyl-1H- 1, 2, 3-triazole by lithiation in anhydrous tetrahydrofurane in the presence of benzonitrile. ...