Hybrid α-bromoacryloylamido chalcones. Design, synthesis and biological evaluation

…, O Cruz-Lopez, CL Cara, J Balzarini, E Hamel…

Index: Romagnoli, Romeo; Baraldi, Pier Giovanni; Carrion, Maria Dora; Cruz-Lopez, Olga; Cara, Carlota Lopez; Balzarini, Jan; Hamel, Ernest; Canella, Alessandro; Fabbri, Enrica; Gambari, Roberto; Basso, Giuseppe; Viola, Giampietro Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 7 p. 2022 - 2028

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Citation Number: 37

Abstract

Research into the anti-tumor properties of chalcones has received significant attention over the last few years Two novel large series of α-bromoacryloylamido chalcones 1a–m and 2a– k containing a pair of Michael acceptors in their structures, corresponding to the α- bromoacryloyl moiety and the α, β-unsaturated ketone system of the chalcone framework, were synthesized and evaluated for antiproliferative activity against five cancer cell lines. ...