A Facile Synthesis of Novel Bis??(indolyl)??1, 3, 4??oxadiazoles as Potent Cytotoxic Agents

D Kumar, V Arun, N Maruthi Kumar, G Acosta…

Index: Kumar, Dalip; Arun; MaruthiKumar; Acosta, Glen; Noel, Brett; Shah, Kavita ChemMedChem, 2012 , vol. 7, # 11 p. 1915 - 1920

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Citation Number: 8

Abstract

Natural products that are selectively toxic towards cancer cells have attracted significant interest among medicinal chemists due to their specificity.[1] In particular, indole-based alkaloids play a versatile role in imparting cytotoxicity to many naturally occurring anticancer agents.[2] Figure 1 shows examples of bis-(indole)-derived natural products. Recently, bis (indole) alkaloids isolated from marine organisms have emerged as a new class of indole- ...