Discovery of {1-[4-(2-{hexahydropyrrolo [3, 4-c] pyrrol-2 (1H)-yl}-1H-benzimidazol-1-yl) piperidin-1-yl] cyclooctyl} methanol, systemically potent novel non-peptide …

…, E Nakata, A Morita, K Mizuno, K Yamamura…

Index: Hayashi, Shigeo; Nakata, Eriko; Morita, Asato; Mizuno, Kunihiko; Yamamura, Kenzo; Kato, Aki; Ohashi, Katsuyo Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 21 p. 7675 - 7699

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Citation Number: 18

Abstract

Neuropathic pain is a serious chronic disorder caused by lesion or dysfunction in the nervous systems. Endogenous nociceptin/orphanin FQ (N/OFQ) peptide and N/OFQ peptide (NOP) receptor [or opioid-receptor-like-1 (ORL1) receptor] are located in the central and peripheral nervous systems, the immune systems, and peripheral organs, and have a crucial role in the pain sensory system. Indeed, peripheral or intrathecal N/OFQ has displayed ...