Synthesis and Studies of Alkynyl Pyrimidinones as Metaphase

TBG Kellen, J Solberg, R Oftebrob…

Index: Solberg, Jan; Benneche, Tore; Undheim, Kjell Acta Chemica Scandinavica, 1989 , vol. 43, # 1 p. 69 - 73

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Abstract

Methods are described for the syntheses of chloromethyl propargyl ethers and propargyl halides substituted with a hydroxyalkyl group, and their use in alkylation reactions of 2- pyrimidinoses. The N-alkynyl derivatives are reversible inhibitors of mitosis in the