1H, 13C and 15N NMR spectral analysis of substituted 1, 2, 3, 4??tetrahydro??pyrido [1, 2??a] pyrimidines

U Girreser, U Bluhm, B Clement…

Index: Girreser, Ulrich; Bluhm, Ullvi; Clement, Bernd; Heber, Dieter Magnetic Resonance in Chemistry, 2013 , vol. 51, # 11 p. 714 - 721

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Abstract

Some years ago, we presented a simple synthetic approach to enone Mannich bases 2 via condensation of aromatic ketones 1 with paraformaldehyde (Scheme 1).[1] These enone Mannich bases could be condensed with a number of bifunctional nucleophiles [2] like amidines [3] or aminopyridines [4] in order to access the corresponding heterocyclic derivatives such as tetrahydropyrimidines or pyrido [1, 2-a] pyrimidines, some structures ...