seco-Cyclothialidines: New Concise Synthesis, Inhibitory Activity toward Bacterial and Human DNA Topoisomerases, and Antibacterial Properties §
…, R Hanke, R Endermann, L Johannsen…
Index: Rudolph; Theis; Hanke; Endermann; Johannsen; Geschke Journal of Medicinal Chemistry, 2001 , vol. 44, # 4 p. 619 - 626
Full Text: HTML
Citation Number: 167
Abstract
seco-Cyclothialidines are a promising class of bacterial DNA gyrase B subunit inhibitors. A new seco-cyclothialidine derivative containing a dioxazine moiety, BAY 50-7952, was synthesized through a new concise pathway. One key step of the synthesis is the straightforward formation of the 2-aminothiazole derivative of S-tritylcysteine. In biological tests, BAY 50-7952 and other known seco-cyclothialidines exhibited high and selective ...
Related Articles:
[Braslau, Rebecca; Rivera III, Frank; Tansakul, Chittreeya Reactive and Functional Polymers, 2013 , vol. 73, # 4 p. 624 - 633]
An iminodiacetic acid based lanthanide binding tag for paramagnetic exchange NMR spectroscopy
[Swarbrick, James D.; Ung, Phuc; Chhabra, Sandeep; Graham, Bim Angewandte Chemie - International Edition, 2011 , vol. 50, # 19 p. 4403 - 4406]
[Platen, Martin; Steckhan, Eberhard Liebigs Annalen der Chemie, 1984 , # 9 p. 1563 - 1576]