Palladium??Catalysed Synthesis of 9H??Pyrrolo [1, 2??a] indol??9??ones and the Isomeric Indeno [2, 1??b] pyrrol??8??ones

…, J Dong, C Li, L Sun, C Song, J Chang

Index: Wang, Shuyang; Yang, Qinghua; Dong, Jingjing; Li, Changwei; Sun, Li; Song, Chuanjun; Chang, Junbiao European Journal of Organic Chemistry, 2013 , # 33 p. 7631 - 7634

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Citation Number: 2

Abstract

The palladium-catalysed amination reaction has found widespread application in the construction of heterocycles, as well as in natural-product synthesis.8 However, to the best of our knowledge, this reaction has never been used for fluorazone synthesis. In this paper, we report a one-pot process consisting of a detosylation and a palladium-catalysed intramolecular amination reaction of 2-bromophenyl N-tosyl-2-pyrrolyl ketones 1 for the synthesis of fluorazones 2 ( ...