Tandem photochemical synthesis of N-amino. beta.-lactams from pyrazolidin-3-ones

…, SC Slater, SG Toske, JD White

Index: Perri, Steven T.; Slater, Stacey C.; Toske, Steven G.; White, James D. Journal of Organic Chemistry, 1990 , vol. 55, # 24 p. 6037 - 6047

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Citation Number: 44

Abstract

" Method A: n-C4HBOH-C6H,, A1203 (cat.), reflux. Method B: C2H5 (of" late generation" antibiotics that possess antibacterial activity comparable to penicillins and cephalo~ porins.~ The first totally synthetic monobactam, aztreonam (l), exemplifies some of the attributes inherent in this family. 6