Tetrahedron Letters

Preparation of unsymmetrical dialkyl acetylenedicarboxylates and related esters by enzymatic transesterification

N Sultan, C Thomas, L Blanco, S Deloisy

Index: Sultan, Nisrine; Thomas, Coralie; Blanco, Luis; Deloisy, Sandrine Tetrahedron Letters, 2011 , vol. 52, # 27 p. 3443 - 3446

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Abstract

Abstract An unexpected highly selective mono-transesterification of symmetrical acetylenedicarboxylates with various alcohols occurred in the presence of Candida rugosa lipase. This reaction allows an efficient preparation of unsymmetrical acetylenedicarboxylates and related α, β-acetylenic esters.