Synthesis of a new series of 2, 8-disubstituted-2, 8-diazaspiro [4, 5] decan-1-ones as potential muscarinic agonists

G Cignarella, S Villa, F Cattabeni, F Reno…

Index: Cignarella; Villa; Cattabeni; Reno; Cimino; De Benedetti; Barlocco European Journal of Medicinal Chemistry, 1994 , vol. 29, # 12 p. 955 - 961

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Citation Number: 2

Abstract

Abstract A new series of 2, 8-disubstituted-2, 8-diazaspiro [4, 5] decan-1-ones 2 has been synthesized and tested for affinity towards muscarinic receptors by binding studies in comparison with the model RS-86. The membrane phosphatidylinositol turnover in the presence or absence of carbachol has also been investigated. In both experiments all the new derivatives 2 were found to be less active than the model; only 5g, which retains the ...