Sulfonyl fluorides as intermediates in organic synthesis. II. Synthesis and alkaline hydrolysis of 2-(acylacetyl) aminothiazoles containing fluorosulfonyl substituents

AD Cat, RV Poucke, M Verbrugghe

Index: De Cat,A. et al. Journal of Organic Chemistry, 1965 , vol. 30, p. 1498 - 1502

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Citation Number: 9

Abstract

The condensation of p-ketonic esters with amino- RCOCH2COOCzHs+ HzNXSOzF- benzenesulfonyl fluorides and the subsequent alkaline hydrolysis of the resulting N- (acylacetyl) aminobensenesulfonyl fluorides have been described in a previous paper.'This method, which is illustrated by the following reaction, proved to be a generally useful synthetic way to N-(acylacety1) aminoarylsulfonates (X= aryl). It has now been extended ...