6-Aryl-4, 5-dihydro-3 (2H)-pyridazinones. A new class of compounds with platelet aggregation inhibiting and hypotensive activities

…, J Gries, H König, R Kretzschmar, J Kunze…

Index: Thyes; Lehmann; Gries; Koenig; Kretzschmar; Kunze; Lebkuecher; Lenke Journal of Medicinal Chemistry, 1983 , vol. 26, # 6 p. 800 - 807

Full Text: HTML

Citation Number: 84

Abstract

1 13 hydropyridazinones I1 in which R'and R2 are hydrogen and R3NH is a para substituent. Cyclization of 40 and 41 with hydrazine hydrate gave the amino-and (acetyl- amino) dihydropyridazinones 1 and 3, respectively. Heating 1 in formic acid gave the formylamino compound 2.8 Treating the amino acid 41 with formic acid led to the y-keto acid 42, which with hydrazine hydrate again gave 2. The (alkanoy1amino) phenyl derivatives 4 ...