Synthesis of menaquinones

CD Snyder, H Rapoport

Index: Snyder,C.D.; Rapoport,H. Journal of the American Chemical Society, 1974 , vol. 96, p. 8046 - 8054

Full Text: HTML

Citation Number: 68

Abstract

Abstract: Various approaches to the synthesis of menaquinones have been studied in which the aromatic component is activated to encourage nucleophilic attack upon a receptive prenyl fragment. Thus alkylation of the potassium salt of 2-methyl-1, 4-naphthoquinol or 4- methoxy-3-methyl-1-naphthol with geranyl bromide gave menaquinone-2 in 20 and 45% yield, re-spectively, following oxidation to the quinone. Hydrogenolysis of the dimethyl ...