New short step general synthesis of isobenzofuran-1 (3H)-ones (phthalides) based on a single or double β-scission of alkoxyl radicals generated from 1-ethyl- …

K Kobayashi, M Itoh, A Sasaki, H Suginome

Index: Kobayashi, Kazuhiro; Itoh, Masahito; Sasaki, Akiyoshi; Suginome, Hiroshi Tetrahedron, 1991 , vol. 47, # 29 p. 5437 - 5452

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Citation Number: 27

Abstract

New general methods are described for the synthesis of phthalides, 3-monosubstituted, and 3, 3-disubstituted phthalides including naturally-occurring phthalides such as pierardine based on a regioselective single or double β-scission of the alkoxyl radicals generated by the photolysis of the hypoiodites of 1-ethyl benzocyclobuten-1-ols or 1, 2-catacondensed benzocyclobuten-1-ols or 1, 3-dihydro-1, 3-alkanoisobenzofuran-1-ols. The formation ...