Application of high pressure, induced by water freezing, to the direct asymmetric aldol reaction
Y Hayashi, W Tsuboi, M Shoji, N Suzuki
Index: Hayashi, Yujiro; Tsuboi, Wataru; Shoji, Mitsuru; Suzuki, Noriyuki Tetrahedron Letters, 2004 , vol. 45, # 22 p. 4353 - 4356
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Citation Number: 53
Abstract
The direct asymmetric catalytic aldol reaction is one of the most important carbon–carbon bond forming reactions, and excellent results for it have recently been published; [6] and [7] one of which is an elegant, proline-mediated aldol reaction between acetone and aldehydes, by List and co-workers 7 As the reaction is synthetically useful, we applied our high pressure system to it, expecting a higher enantioselectivity due to the lower reaction temperature, which ...
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