Exploring naphthyl-carbohydrazides as inhibitors of influenza A viruses

…, V Codrea, G Kago, R Edupuganti, J Robertus…

Index: Barman, Sanmitra; You, Lei; Chen, Ran; Codrea, Vlad; Kago, Grace; Edupuganti, Ramakrishna; Robertus, Jon; Krug, Robert M.; Anslyn, Eric V. European Journal of Medicinal Chemistry, 2014 , vol. 71, p. 81 - 90

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Citation Number: 7

Abstract

Abstract A library of hydrazide derivatives was synthesized to target non-structural protein 1 of influenza A virus (NS1) as a means to develop anti-influenza drug leads. The lead compound 3-hydroxy-N-[(Z)-1-(5, 6, 7, 8-tetrahydronaphthalen-2-yl) ethylideneamino] naphthalene-2-carboxamide, which we denoted as “HENC”, was identified by its ability to increase the melting temperature of the effector domain (ED) of the NS1 protein, as ...