Microwave-assisted synthesis of novel 1, 2, 3-triazole derivatives and their antimicrobial activity

D Ashok, DM Gandhi, G Srinivas, AV Kumar

Index: Ashok; Mohan Gandhi; Srinivas; Vikas Kumar Medicinal Chemistry Research, 2014 , vol. 23, # 6 p. 3005 - 3018

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Citation Number: 21

Abstract

Abstract An environmentally benign and economic synthesis of 1-[7-(1-benzyl-1 H-[1, 2, 3] triazol-4-ylmethoxy)-2, 2-dimethyl-chroman-6-yl]-3-aryl-2-propen-1-ones and 1-[5-(1-benzyl- 1 H-[1, 2, 3] triazol-4-ylmethoxy)-2, 2-dimethyl-chroman-6-yl]-3-aryl-propen-1-ones is described. The procedure takes place by the 1, 3-dipolar cycloaddition (''click-reaction'') between azides and alkynes catalysed by copper (I) salts. The simplicity of this reaction ...