An improved procedure for nucleoside synthesis using glycosyl trifluoroacetimidates as donors
J Liao, J Sun, B Yu
Index: Liao, Jinxi; Sun, Jiansong; Yu, Biao Carbohydrate Research, 2009 , vol. 344, # 8 p. 1034 - 1038
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Citation Number: 9
Abstract
The exceptional importance of nucleic acids in life science has fueled the development of chemical synthesis methodologies of nucleosides. To date, three types of chemical synthesis strategies have been employed: (1) condensation of the sugar moiety and the base directly; (2) construction of the base moiety after introduction of a functional group at the anomeric position of the sugar moiety; (3) derivatization of naturally occurring nucleosides. 5 Compared to the last two, ...
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