Synthesis and neuroleptic activity of N-[(1-ethyl-2-pyrrolidinyl) methyl]-2-methoxy-5-sulfonamidobenzamides

M Ogata, H Matsumoto, S Kida, T Shiomi…

Index: Ogata, Masaru; Matsumoto, Hiroshi; Kida, Shiro; Shiomi, Teruo; Eigyo, Masami; Hirose, Katsumi Journal of Medicinal Chemistry, 1984 , vol. 27, # 9 p. 1137 - 1141

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Citation Number: 3

Abstract

A series of some novel N-[(l-ethyl-2-pyrrolidinyl) methyl] benzamides involving replacement of the sulfarnoyl group in sulpiride with a sulfonamido group was synthesized and tested for dopamine receptor blockade. In comparison with sulpiride, several compounds were considerably more potent than sulpiride as dopamine receptor blockers. The structure- activity relationships are discussed.