Synthetic calanolides with bactericidal activity against replicating and nonreplicating Mycobacterium tuberculosis

…, S Somersan-Karakaya, S Lu, J Roberts…

Index: Zheng, Purong; Somersan-Karakaya, Selin; Lu, Shichao; Roberts, Julia; Pingle, Maneesh; Warrier, Thulasi; Little, David; Guo, Xiaoyong; Brickner, Steven J.; Nathan, Carl F.; Gold, Ben; Liu, Gang Journal of Medicinal Chemistry, 2014 , vol. 57, # 9 p. 3755 - 3772

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Citation Number: 21

Abstract

It is urgent to introduce new drugs for tuberculosis to shorten the prolonged course of treatment and control drug-resistant Mycobacterium tuberculosis (Mtb). One strategy toward this goal is to develop antibiotics that eradicate both replicating (R) and nonreplicating (NR) Mtb. Naturally occurring (+)-calanolide A was active against R-Mtb. The present report details the design, synthesis, antimycobacterial activities, and structure–activity ...