Design, synthesis and in vivo hypoglycemic activity of tetrazole-bearing N-glycosides as SGLT2 inhibitors

YL Gao, GL Zhao, W Liu, H Shao, YL Wang…

Index: Gao; Zhao; Liu; Shao; Wang; Tang Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2010 , vol. 49, # 11 p. 1499 - 1508

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Citation Number: 32

Abstract

Abstract: Novel tetrazole-bearing N-glycosides have been designed and synthesized as SGLT2 inhibitors via a conventional protocol starting from substituted phenylacetic acids and two monosaccharides, d-glucose and d-galactose, and their hypoglycemic activity has been tested in vivo by mice oral glucose tolerance test (OGTT). Two compounds are found to be more potent than the positive control Dapagliflozin. The structure-activity relationship has ...