Tetrahedron Letters

Silver-catalyzed cross-coupling reactions of alkyl bromides with alkyl or aryl Grignard reagents

H Someya, H Yorimitsu, K Oshima

Index: Someya, Hidenori; Yorimitsu, Hideki; Oshima, Koichiro Tetrahedron Letters, 2009 , vol. 50, # 26 p. 3270 - 3272

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Citation Number: 24

Abstract

Treatment of secondary or tertiary alkyl bromides with alkyl Grignard reagents in the presence of catalytic amounts of silver bromide and potassium fluoride in CH2Cl2 afforded the corresponding cross-coupling products in reasonable yields. Moreover, silver showed catalytic activity for the cross-coupling reactions of alkyl bromides with aryl Grignard reagents.