Facile synthesis of pyrazoles and pyrroles via thermolysis of tetrazolo [1, 5-b] pyridazines, tetrazolo [1, 5-a] pyrimidines and tetrazolo [1, 5-a] pyridines
D Simoni, R Rondanin, G Furnò, E Aiello, FP Invidiata
Index: Simoni, Daniele; Rondanin, Riccardo; Furno, Giancarlo; Aiello, Enrico; Invidiata, Francesco Paolo Tetrahedron Letters, 2000 , vol. 41, # 15 p. 2699 - 2703
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Citation Number: 15
Abstract
A simple and high yielding preparation of pyrazoles and pyrroles is described. Thermolysis of tetrazolo [1, 5-b] pyridazines, tetrazolo [1, 5-a] pyrimidines and tetrazolo [1, 5-a] pyridines allowed easy ring contraction thus providing a facile preparation of cyanopyrazole and cyanopyrrole heterocycles. Since the cyano group is a versatile precursor of other functionalities, the reaction appears of particular interest for the construction of a variety of ...
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