Sulfonamide chalcone as a new class of α-glucosidase inhibitors

…, JH Kim, JE Kang, HW Ryu, MJ Curtis-Long…

Index: Seo, Woo Duck; Kim, Jin Hyo; Kang, Jae Eun; Ryu, Hyung Won; Curtis-Long, Marcus J.; Lee, Hyun Sun; Yang, Min Suk; Park, Ki Hun Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 24 p. 5514 - 5516

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Citation Number: 96

Abstract

Chalcones 1–20, a new class of glycosidase inhibitors, were synthesized, and their glycosidase inhibitory activities were investigated. Non-aminochalcones 1–12 had no inhibitory activity, however, aminochalcones 13–20 had strong glycosidase (α-glucosidase, α-amylase, and β-amylase) inhibitory activities. In particular, sulfonamide chalcones 17–20 had more potent α-glucosidase inhibitory activity than aminated chalcone 13–16. 4′-(p- ...