A general amination method based on the addition of polyfunctional arylmagnesium reagents to functionalized arylazo tosylates

I Sapountzis, P Knochel

Index: Sapountzis, Ioannis; Knochel, Paul Angewandte Chemie - International Edition, 2004 , vol. 43, # 7 p. 897 - 900

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Citation Number: 77

Abstract

The preparation of polyfunctional diarylamines of type 1 is an important goal in synthesis since these building blocks are present in many pharmaceuticals and various fine chemicals. There are two approaches to such target molecules [1] involving either the generation of a nucleophilic amino synthon 2 which will react with an electrophilic aromatic reagent (Ar+XÀ 3, path a in Scheme 1). This retrosynthetic analysis has been successfully ...