Bioorganic & medicinal chemistry letters

Synthesis and anticancer activity of thiosemicarbazones

W Hu, W Zhou, C Xia, X Wen

Index: Hu, Wei-Xiao; Zhou, Wei; Xia, Chun-Nian; Wen, Xi Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 8 p. 2213 - 2218

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Citation Number: 123

Abstract

Twenty-six thiosemicarbazones (III-1–III-26) were synthesized via three steps starting from hydrazine hydrate and carbon disulfide. The testing of anticancer activity of these compounds in vitro against P-388, A-549, and SGC-7901 shows that compounds III-15 and III-16 possess a higher inhibitory ability for P-388 and SGC-7901. Further testing shows that the value of IC50 of compound III-16 against SGC-7901 reaches to 0.032 μM.