Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase

…, JÉ Debreczeni, OY Fedorov, A Nelson…

Index: Bartlett, Stephen; Nelson, Adam Organic and Biomolecular Chemistry, 2004 , vol. 2, # 19 p. 2874 - 2883

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Citation Number: 137

Abstract

The kinase PIM-1 plays a pivotal role in cytokine signaling and is implicated in the development of a number of tumors. The three-dimensional structure of PIM-1 is characterized by an unique hinge region which lacks a second hydrogen bond donor and