Syntheses, transfection efficacy and cell toxicity properties of novel cholesterol-based gemini lipids having hydroxyethyl head group

…, SK Mishra, P Kondaiah, S Bhattacharya

Index: Biswas, Joydeep; Mishra, Santosh K.; Kondaiah, Paturu; Bhattacharya, Santanu Organic and Biomolecular Chemistry, 2011 , vol. 9, # 12 p. 4600 - 4613

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Citation Number: 16

Abstract

We have synthesized five new cholesterol based gemini cationic lipids possessing hydroxyethyl (-CH2CH2OH) function on each head group, which differ in the length of the polymethylene spacer chain. These gemini lipids are important for gene delivery processes as they possess pre-optimized molecular features, eg, cholesterol backbone, ether linkage and a variable spacer chain between both the headgroups of the gemini lipids. Cationic ...